R. Woodford, B. W. Barry
Sep 1, 1985
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
International Journal of Pharmaceutics
Abstract
Abstract This study investigates the vasoconstrictor activities and bioavailabilities and, by inference, the clinical anti-inflammatory efficacies of cream and ointment formulations of a new steroid, Timobesone acetate (an etianic acid derivative of betamethasone in which the terminal carbon (C-21) of the corticoid side-chain has been replaced by a thiomethyl group and the 17α-hydroxy by an acetate ester group). These preparations were compared with selected commercially available steroid creams and ointments (Lidex, Dermovate and Betnovate) in the occluded and non-occluded blanching tests in 10 volunteers. From the vasoconstrictor data and the absence of any untoward effects, it was concluded that the Timobesone formulations were active, bioavailable and showed promise for future clinical use.