E. Fride, R. Mechoulam
Feb 9, 1993
Citations
14
Influential Citations
447
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Quality indicators
Journal
European journal of pharmacology
Abstract
Anandamide (arachidonylethanolamide) is a brain constituent which binds to the cannabinoid receptor. We now report the first in vivo examination of this ligand. Anandamide administered i.p. in mice, caused lowering of activity in an immobility and in an open field test, and produced hypothermia and analgesia. These effects parallel those caused by psychotropic cannabinoids.