A. L. Beyler, E. Neumann, D. F. Burnham
Apr 1, 1956
Citations
0
Influential Citations
3
Citations
Journal
Endocrinology
Abstract
MARKED qualitative and quantitative alterations in biological activity often follow minor changes in the structural features of the steroid hormones. This fact has been cogently demonstrated by the recent introduction of two new synthetic steroids, Δ1,4-pregnadiene-17α;,21-diol- 3,11,20-trione (Δ1-Cortisone) and Δ1,4-pregnadiene-llβ,17α,21-triol-3,20- dione (Δ1Cortisol). The chemistry and clinical effectiveness of these derivatives of Cortisone and Cortisol have been reported (Herzog, et al, 1955; Bunim, Pechet and Bollet, 1955; Gray and Merrick, 1955). Δ1,4-Pregnadiene-21-ol-3,20-dione, 3-acetate (hereafter referred to as Δ1DCA) was synthesized in our laboratories by Clarke et al. (1955). This new steroid differs chemically from DCA (Δ4-Pregnene-21-ol-3,20-dione, 3-acetate) in that it possesses a double bond in the 1:2 position of ring A of the steroid nucleus as do A∧Cortisone and Δ1-Cortisol. The purpose of this report is to describe certain of the biological activities of Δ1-DCA which are compared wit...