S. Parmar, P. C. Joshi, B. Ali
Jun 1, 1974
Citations
0
Influential Citations
14
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
Several 2,5-disubstituted 1,3,4-oxadiazoles were synthesized, characterized, and tested for their effectiveness in inhibiting the respiratory activity of rat brain homogenate. All substituted oxadiazoles and their precursors, thiosemicarbazides, were found to inhibit nicotinamide adenine dinucleotide- (NAD) dependent oxidations of pyruvate and α-ketoglutarate as well as the NAD-independent oxidation of succinate. Anticonvulsant activity, as exhibited by protection against pentylenetetrazol-induced seizures, with substituted thiosemicarbazides and the corresponding cyclized oxadiazoles ranged from 30 to 90% at a dose of 100 mg/kg. The degree of protection afforded by these compounds, however, was unrelated to their ability to inhibit oxidation of pyruvate, α-ketoglutarate, and succinate.