H. Friedman, S. Keir, P. Houghton
Aug 1, 2001
Citations
1
Influential Citations
18
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Quality indicators
Journal
Cancer Chemotherapy and Pharmacology
Abstract
Abstract.Purpose: This study was conducted to define the activity of irofulven in the treatment of a series of xenografts derived from human glioblastoma multiforme growing subcutaneously and intracranially in athymic nude mice. Methods: Athymic mice bearing subcutaneous or intracranial tumors were treated with irofulven at a 10% lethal dose with responses compared to tumor-bearing mice treated with drug vehicle. Results: Irofulven was active against all tumor lines tested with growth delays ranging from 5.6 to 81.6 days (all values statistically significant, P≤0.001). Irofulven also produced a statistically significant (P≤0.001) increase in the median survival of mice bearing D-456 intracranial xenografts with a 162% increase in median survival. Conclusions: Irofulven is active in a spectrum of human glioblastoma multiforme-derived xenografts and evaluation in patients with this neoplasm is warranted.