K. Kinnamon, E. Steck, P. S. Loizeaux
Jul 1, 1978
Citations
3
Influential Citations
58
Citations
Quality indicators
Journal
The American journal of tropical medicine and hygiene
Abstract
A series of lepidines (6-methoxy-4-methyl-8-aminoquinoline derivatives) was studied in a hamster-Leishmania donovani model. Members of this class were found to have activity many-fold that of the standard, meglumine antimoniate (Glucantime). One of them, 8-(6-diethylamino-hexylamino)-6-methoxy-4-methylquinoline, designated WR 6026, when given orally was over 700 times as effective as the standard antimonial drug.