Okunrobo O. Lucky, Owolabi J. Omonkhelin
May 6, 2009
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Quality indicators
Journal
Pharmaceutical Chemistry Journal
Abstract
The synthesis of 3-benzamido-1-(4-(2-methoxyphenyl) piperazin-1-yl)-propyl-2-isopropylcarboxamide (BPC) was accomplished by treating N-3-(4-(2-methoxyphenyl)piperazin-1-yl)-propyl-2-isopropylphthalimide with isopropylamine in dimethylformamide at room temperature. The compound was characterized spectroscopically. At concentrations of 0.05 and 0.1 mg/ml, 3-benzamido-1-(4-(2-methoxyphenyl)piperazin-1-yl)-propyl-2-isopropylcarboxamide (BPC) produced a significant inhibition of oxytocin (p < 0.05) and acetylcholine (p < 0.0001) induced contractions of the uterine smooth muscle in non-pregnant rats in a dose-dependent manner. From the results obtained it may be inferred that this compound is probably acting via muscarinic receptors.