R. Niero, Ana P. Mafra, Ana C Lenzi
Dec 1, 2006
Citations
0
Influential Citations
25
Citations
Quality indicators
Journal
Natural Product Research
Abstract
A new triterpene 3,15-dioxo-21α-hydroxy friedelane has been isolated from methanol extract of Maytenus robusta and its structure elucidated on the basis of spectral analysis. Stigmasterol, friedelin, friedelanol and 3,15-dioxo friedelane were also obtained. 3,15-dioxo-21α-hydroxy friedelane was analyzed against the writhing test in mice and exhibited potent dose-dependent effects with an ID50 value of 12.5 ± 2.1 µmol kg−1 and a maximal inhibition of 85.90%. It was about 10-fold more active than aspirin and paracetamol, used as reference drugs.