E. Jang, Hyo Kyeong Kim, Hana Jeong
Jun 1, 2014
Citations
1
Influential Citations
17
Citations
Quality indicators
Journal
Chemistry & Biodiversity
Abstract
Antofine (ANTF) is a phenanthroindolizidine alkaloid isolated from the root of Cynanchum paniculatum Kitagawa (Asclepiadaceae), which is used as an herbal remedy for pain and inflammation. ANTF also possesses antiviral and antitumorigenic activities. In this study, we investigated the role of ANTF in adipogenesis. Chronic ABTF administration suppressed adipocyte differentiation and marker expression in a dose‐dependent manner. Furthermore, acute administration of ANTF at early stages of differentiation process inhibited lipid droplet formation and adipogenic gene expression. ANTF Treatment decreased expression of PPARγ protein, a master transcription factor in the regulation of adipocyte differentiation, leading to a suppression of aP2 promoter activity. These results suggest that ANTF exerts potent anti‐adipogenic effects via direct suppression of PPARγ protein expression, with consequent downregulation of adipogenic gene expression.