R. Prakin, H. B. Waynforth, P. Magee
Jun 1, 1973
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0
Influential Citations
30
Citations
Quality indicators
Journal
Mutation research
Abstract
Abstract N -Nitroso- N -methylurea (NMU) at a dose of 50 mg/kg body wt significantly increased the incidence of early foetal death (dominant lethal mutations) when compared with the solvent controls in the mouse dominant lethal test. The mutagenic activity of NMU was considerably less than that of methyl methanesulphonate (MMS) which was used as a positive control mutagen but, in comparison, it affected a greater part of the spermatogenic cycle of the treated male mice. N -Methyl- N -nitroso- N ′-nitroguanidine (MNNG) produced a small increase in dominant lethal mutations with a low level of significance ( P 50 dose of 100 mg/kg. At this dose level the mutagenic activity was confined to the first 4 days of the first week. N -Nitrosomorpholine could not be tested during the first 3 to 4 weeks of the assay at dose levels of 50 and 100 mg/kg due to an adverse effect on mating activity but no increase in the incidence of dominant lethal mutations was observed between the 5th and 8th week. At a dose of 35 mg/kg mating activity was normal during the initial 3-week period studied but there was no evidence of increased mutations.