Riazuddin Mohammed, A. Samaunnisa, Venkataramana C.H.S.
May 30, 2014
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International journal of biomedical research
Abstract
In the present work, screening for antihypertensive activity was carried out on a series of sixteen novel 2, 6-dimethyl-N 3 , N 5 -diphenyl-1, 4- dihydropyridine-3, 5-dicarbohydrazides (2A-2D') and 2,6-dimethyl-1,4-dihydropyridine-3,5-yl-bis(carbonyl-2- (phenyl))pyrazolidine-3,5-diones) (3A- 3D') derivatives. Structures of all the derivatives were previously confirmed by IR, 1 HNMR, mass and elemental analysis data. These derivatives contain central 1,4-dihydropyridine ring which is renowned for its calcium channel blocking activity. Antihypertensive activity was evaluated usi ng tail cuff method in rats. Nifedipine was used as standard and 1% w/v sodium carboxy methyl cellulose suspension as control. Most of the compounds exhibited appreciable antihypertensive activity and are significant when compared with the standard. The Systolic Blood Press ure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Blood Pressure (MABP) were measured in both normotensive and hypertensive rats.