T. Fritsche, P. Rhomberg, H. Sader
Jan 7, 2008
Citations
0
Influential Citations
40
Citations
Quality indicators
Journal
Antimicrobial Agents and Chemotherapy
Abstract
ABSTRACT Omiganan, a bactericidal and fungicidal cationic peptide being developed as a topical gel for prevention of catheter-associated infections, inhibited commonly occurring fungal pathogens including Candida spp. (106 isolates) at ≤256 μg/ml and molds (including 10 Aspergillus isolates) at ≤1,024 μg/ml. All fungi were inhibited by omiganan at concentrations well below the 1% (10,000 μg/ml) clinical formulation, including species with reduced susceptibility to azoles and echinocandins.