E. Ishii
Sep 1, 1993
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Zentralblatt fur Bakteriologie : international journal of medical microbiology
Abstract
Teprenone, a non water-soluble antiulcer agent, is a derivative of terpene. The antibacterial activity of teprenone against Helicobacter pylori was examined by the disc method and survival test in albumin broth including teprenone. Growth of H. pylori around the disc charged with teprenone was inhibited on Brucella agar supplemented with bovine serum albumin fraction V, charcoal, or beta-cylodextrin, but not with blood or egg yolk emulsion. Furthermore, when H. pylori was exposed in broth including teprenone, H. pylori did not survive after 20 hours at 0.25 approximately 10 ppm. These results indicate that teprenone has antibacterial activity against H. pylori.