M. F. Souza, G. Cunha, J. Fontenele
Dec 1, 1994
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Influential Citations
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Quality indicators
Journal
Phytotherapy Research
Abstract
Ternatin, a tetramethoxy flavone isolated from Egletes viscosa Less. was evaluated for a possible antithrombotic acitivity on in vitro platelet aggregation induced by ADP and in vivo mouse model of tail thrombosis induced by kappa‐carrageenan (KC). ADP‐induced platelet aggegation was inhibited by ternatin in a concentration‐dependent manner with an IC50 of 390 μM. It also provided marked protection of mice from thrombotic challenge with KC. Tail thrombosis was totally prevented in mice that received ternatin prophylactically (1 h prior to KC injection) whereas therapeutically (4 h after KC injection) administered ternatin effectively reduced the length of the thrombosed/infarcted part of the tail. The observations suggest an antithrombotic action of ternatin.