M. El-Gaby, J. Micky, N. Taha
Jun 1, 2002
Citations
0
Influential Citations
28
Citations
Journal
Journal of The Chinese Chemical Society
Abstract
Thiophosgenation of sulfonamides 1a-c in the presence of dilute HCl at room temperature furnished the isothiocyanatosulfonamides 2a-c and treatment with aromatic amines gave 1,3-disubstituted thioureas 3a,b. Also, interaction of two molecules of 2c with 1,4-phenylenediamine yielded the novel bisthiourea 4. Cyclocondensation of 2 with ortho amino carboxylic acid compounds such as anthranilic acids 8, 5-amino-1-phenyl-pyrazol-4-carboxylic acid 9 and 4,5,6,7-tetrahydro-2-amino-benzo[b]thiophene-3-carboxylic acid 10 furnished the fused thiopyrimidines 11a-d, 12 and 13, respectively. 2-Anilinobenzoazole derivatives 15a-c, 16a, b and 17a,b were obtained through cyclocondensation of 2 with 1,2-dinucleophiles.