Bhupinder Singh, A. Saxena, B. Chandan
Jul 28, 1998
Citations
1
Influential Citations
129
Citations
Quality indicators
Journal
Fitoterapia
Abstract
The effects of an oral administration of verbenalin were studied for its hepatoprotective activity. Hexobarbitone-induced sleeping time, zoxazolamine-induced paralysis time, bromosulphalein (BSP) retention, serum levels of transominases, bilirubin and total protein were used as indices of liver injury. A significant hepatoprotective effect was observed as evident from shortened hexobarbitone sleeping time and zoxazolamine paralysis time in mice which were increased by CCl 4 treatment. Further, pre- and post-treatment with verbenalin reduced plasma BSP in mice, serum transaminases and biliribin in rats in a dose-dependent manner as compared to CCl 4 - treated animals. Verbenalin did not show any sign of toxicity and the minimum lethal dose was greater than 3.0 g/kg when given orally or intraperitoneally in mice.