I. Gaunt, J. Colley, P. Grasso
1969
Citations
3
Influential Citations
32
Citations
Journal
Food and cosmetics toxicology
Abstract
Abstract The LD 50 of cis -3-hexen-1-ol in rats and mice was in the range of 7–10 g/kg by theoral route and 0·4–0·6 g/kg by the intraperitoneal route. In the short-term study, rats were given cis -3-hexen-1-ol in the drinking water at levels of 0 (control), 310, 1250 or 5000 ppm. No effects were seen at 310 and 1250 ppm, but in males of the 5000-ppm group the intake of drinking water was reduced compared with controls, the relative kidney weight was increased and the urine collected in the first 2 hr after a water load was more concentrated. In females, the only finding was a transitory anaemia at this level. The no-effect level was 1250 ppm in the drinking water, equivalent to an intake of 120–150 mg/kg/day, or 5000 times the estimated intake in man.