J. H. Johnson, R. L. Younger, D. A. Witzel
1975
Citations
0
Influential Citations
10
Citations
Journal
Toxicology and applied pharmacology
Abstract
Abstract Thirty adult sheep of both sexes were treated intrarumenally with tricyclohexyltin hydroxide. Groups of five sheep each were treated with 750, 500, and 250 mg/kg; groups of four sheep each were given 150, 25, and 15 mg/kg; and three sheep received 50 mg/kg. All were affected except the sheep treated with 15 mg/kg. Sheep treated with 750 and 500 mg/kg had severe cardiovascular and respiratory changes at necropsy. On dermal treatment, no ill effect was observed in eight yearling cattle (two per group) sprayed with suspensions of 0.025, 0.05, 0.1, and 0.5%. Three yearling cattle were anorectic after being sprayed with the 1.0% suspension. Two baby calves (one per group) tolerated spraying at 0.075 and 0.1%. Fifteen yearling Angora goats (five per group) tolerated exposure by spraying with the 0.025, 0.05, and 0.1% suspensions. Transitory anorexia and eye irritation were noted in three goats sprayed with the 2.0% suspension. Of 15 sheep (five per group) sprayed at 0.025, 0.05, and 0.1%, no ill effect was observed. Three of five sheep were mildly affected when sprayed at 0.5%. At the 1.0% spraying, one sheep was affected and died, three sheep were mildly affected and survived, and one was unaffected. Of two sheep sprayed at 2.0%, one was mildly affected and survived, but the other sheep was affected, aborted, and died of complications.