Lian Xue-ke
2011
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Pharmacy Today
Abstract
Objective To study the acute toxicology of Felbinac Trometamol injection.The result was compared with Ethyl phenylacetate injection which has been marketed in Japan,so as to provide reference for clinical research.Methods NIH mice and Beagle dogs were selected in this study.The maximum tolerable dose(MTD) and approximate lethal dose(ALD) methods were used to study the acute toxicology of Felbinac Trometamol injection.Results The MTD of Felbinac Trometamol injection was 900 mg/kg,and the LD50 of Felbinac Trometamol injection was obviously exceed 900 mg/kg,the ALD of Felbinac Trometamol injection was 405~608 mg/kg(calculated as felbinac).The LD50 of Ethyl phenylacetate injection were 337 mg/kg(male,294.5~347.4) and 433 mg/kg(female,392.3~462.9),the ALD of Ethyl phenylacetate injection was 250~500 mg/kg(calculated as felbinac).Conclusion Compared with Ethyl phenylacetate injection,Felbinac Trometamol injection displays much better in safety,and it may have a good market prospect.