I. Gill, Jagbandhu Das, Ramesh N. Patel
Jun 22, 2007
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
Abstract An efficient biocatalytic process has been developed for the resolution of 1-(3′-bromophenyl)ethylamine ( RS )- 1 by way of enantioselective lipase-mediated ( R )-selective acylation with ethyl 2-methoxyacetate to afford ( S )-amine ( S )- 1 and ( R )-2″-methoxyacetamide (( R )- 2 ) in 91–95% and 90–92% isolated yield, respectively, and both with >99% ee.