H. Tani, N. Oguni, T. Araki
Sep 1, 1964
Citations
0
Influential Citations
5
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
N-Acetyl and N-benzoyl lactams consisting of a five-to-seven-membered ring were found to be good acylation reagents. Several amines were acylated with these reagents to give the corresponding amides in good yields. When N-benzoyl-2-pyrrolidone was used, ring-opened by-products were obtained by the reaction with a secondary amine, such as pyrrolidine and piperidine. Tosylalanyl-2-pyrrolidone reacted with primary amines to produce the corresponding tosylalanine amides. The alanine methyl ester reacted as a primary amine with tosylalanyl-2-pyrrolidone to afford a dipeptide.