Cheol-Hae Lee, M. Westling, T. Livinghouse
May 1, 1992
Citations
0
Influential Citations
33
Citations
Journal
Journal of the American Chemical Society
Abstract
A concise total synthesis of (±)-dendrobine is described that proceeds in eight steps from 2-methylcyclopent-2-en-1-one. The key transformation in this approach is the silver ion mediated cyclocondensation of the isonitrile 6 with the acyl chloride 5. This highly convergent reaction proceeds in excellent (88%) overall yield to provide the Δ 1 -pyrroline 4