H. Ebiike, Y. Terao, K. Achiwa
Oct 7, 1991
Citations
1
Influential Citations
30
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The first practical syntheses of chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates, which are attractive compounds as new calcium antagonists, were realized by lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters. The monoesters obtained were revealed to have high optical purity and demonstrated to be useful chiral synthons.