M. Houslay
Apr 1, 1998
Citations
4
Influential Citations
89
Citations
Quality indicators
Journal
Seminars in cell & developmental biology
Abstract
Cyclic AMP has provided the paradigm for the second messenger concept. Recent evidence has identified a complex array of isoforms of the enzymes involved in generation, destroying and transmitting the effects of this second messenger. These proteins provide a sophisticated system for organising cAMP signal transduction in specific intracellular compartments; for allowing integration with other signalling systems and for controlling the kinetics and hence reaction characteristics of cAMP signal transduction.