K. Kimmel, MaryAnn T. Robak, J. Ellman
Jun 4, 2009
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0
Influential Citations
130
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Quality indicators
Journal
Journal of the American Chemical Society
Abstract
The highly enantioselective addition of thioacetic acid to nitroalkenes using a new sulfinyl urea organocatalyst is described. The addition of thioacetic acid proceeds in high yields and enantioselectivities for a variety of aromatic and aliphatic nitroalkene substrates. This new method is useful for preparing chiral 1,2-aminothiol derivatives, as demonstrated by the first enantioselective synthesis of the clinically used antifungal drug sulconazole.