Takuji Kawamoto, T. Fukuyama, I. Ryu
Jan 18, 2012
Citations
0
Influential Citations
53
Citations
Journal
Journal of the American Chemical Society
Abstract
Hydroxymethylation of alkyl halides was achieved using paraformaldehyde as a radical C1 synthon in the presence of tetrabutylammonium cyanoborohydride as a hydrogen source. The reaction proceeds via a radical chain mechanism involving an alkyl radical addition to formaldehyde to form an alkoxy radical, which abstracts hydrogen from a hydroborate anion.