G. P. Stahly
Apr 1, 1989
Citations
0
Influential Citations
52
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Nucleophilic addition of difluoromethyl phenyl sulfone ( 1 ) to various aldehydes occurred in a two phase system (50% aqueous sodium hydroxide, dichloromethane. Aliquat® 336) to give difluoro(phenylsulfonyl)methyl substituted alcohols ( 2 /2 8 ). The product alcohol derived from para -tolualdehyde was converted to the difluoromethylated alcohol by desulfonylation and to the α, β, β-trifluorostyrene by a fluorination-elimination sequence. In the absence of aldehydes, 1 reacted in the two phase system to give difluoro(phenylsulfonyl)methyl phenyl sulfide ( 9 ). The pathway of the latter conversion was studied.