J.Gregory Reid, Jean H Reny Runge
1990
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron Letters
Abstract
Base-mediated reaction of ortho-nitroaryl chlorides and fluorides with nitroalkanes followed by an oxidative Nef reaction provides aryl ketones. With this simple procedure, methylketone 6 was prepared in 91% yield. 6 was then converted in three steps (60-65% yield) to 4-chloro-7-(trifluoromethyl)quinoline (2), an intermediate in the synthesis of the antihypertensive agent losulazine (U-54,669, 1).