Y. Ukaji, Shoichi Takenaka, Y. Horita
Mar 5, 2001
Citations
0
Influential Citations
24
Citations
Journal
Chemistry Letters
Abstract
The asymmetric nucleophilic addition of Reformatsky-type reagent to imines, which were prepared from aldehydes and 2-aminophenols, was achieved by the use of diisopropyl (R, R)-tartrate as a chiral auxiliary to afford the corresponding β-amino acid ester derivatives with excellent enantioselectivities. In order to realize reproducible higher stereoselection, the addition of a small amount of water was crucial.