G. Mawer, V. Jamieson, S. B. Lucas
Feb 1, 1999
Citations
1
Influential Citations
12
Citations
Quality indicators
Journal
Epilepsia
Abstract
Summary: Purpose: The efficacy of remacemide hydrochloride (REM) as an antiepileptic drug (AED) was tested in a double‐blind, add‐on trial in patients with refractory epilepsy. Concurrent drugs included carbamazepine (CBZ). The interfering effects of the pharmacokinetic interaction between REM and CBZ were offset by the monitoring of plasma CBZ concentration and the appropriate reduction of CBZ dose by an unblinded observer.