P. Bechgaard, A. Bergstrand
Mar 1, 1949
Citations
0
Influential Citations
3
Citations
Journal
Acta endocrinologica
Abstract
Desoxycorticosterone acetate (DCA), the synthetic adrenocortical compound, is extensively used because of its ability to replace the adrenocortical hormones in adrenal insufficiencies of various kinds. The considerable rise of the blood pressure and the effect on the sodium-potassium balance of the organism caused by its administration in, for example, Addison's disease, encouraged attempts to induce an experimental rise of the blood pressure by means of large doses of the preparation. Many investigators have reported that a considerable rise of the blood pressure has been obtained both in experimental animals and in man with large doses of DCA given together with saline (Engel et al. 1942, Ferrebee et al. 1939, Grollman et al. 1940, Perera et al. 1944, Roth et al. 1943, Soffer et al. 1940, Swingle et al. 1941, Thorn, Howard et al. 1939, Thorn, Dorrance & Day, 1942). It is remarkable that