M. Streicher
May 24, 1947
Citations
0
Influential Citations
6
Citations
Journal
Journal of the American Medical Association
Abstract
In the past few years considerable progress has been made in the treatment of chronic ulcerative colitis with the newer intestinal sulfonamide compounds. Phthalylsulfathiazole has been very effective. Essentially, therapeutic results were obtained through the action of sulfonamide compounds against the coliform organisms plus the standard supportive measures. The sulfonamide compounds employed in infectious disease of the colon failed to be efficacious against the staphylococci and the streptococci. With the present knowledge of penicillin and its properties it was thought advisable to employ this agent alone and in combination with phthalylsulfathiazole in chronic ulcerative colitis. The recognition of penicillin as a general antibacterial agent came with the experiments of Fleming 1 in 1929. His researches were corroborated by Reid 2 in 1935 and by Bornstein 3 in 1940. Later the studies were extended in reference to stability by Chain, 4 Florey 5 and Clutterbuck. 6 Abraham, 7 in his studies