D. E. Cherra, S. Khattabi, G. Guiochon
Apr 1, 2000
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0
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32
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Journal
Journal of chromatography. A
Abstract
The single-component and competitive adsorption isotherms of the enantiomers of 3-chloro-1-phenyl-1-propanol were measured by frontal analysis. The stationary phase was a cellulose tribenzoate coated on silica, the mobile phase an n-hexane-ethyl acetate (95:5) solution. The adsorption data measured fitted well to the Langmuir isotherm model. The band profiles of single components and of their mixtures were calculated using the equilibrium-dispersive model. These profiles were found to match quite satisfactorily the experimental band profiles. However, the agreement between calculated and experimental band profiles was significantly improved when a more complex model taking into account the mass transfer kinetics was used. The mass transfer rate coefficients, k(f), for both single components were determined by using the transport-dispersive model of chromatography. The coefficients obtained were used to predict the band profiles of mixtures of the two enantiomers to good agreement.