Wang Jun-ke
2011
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Journal
Chinese Journal of New Drugs and Clinical Remedies
Abstract
Olprinone,a specific phosphodiesterase(PDE)Ⅲ inhibitor,was developed in Japan for the treatment of acute heart failure or early heart failure following cardiac surgery.In recent years,more attention was paid to the other pharmacological effects of olprinone besides heart failure treatment.Olprinone could dilate brain,carotid or renal arteries,etc.,and could be used in treating asthma,increasing diaphragmatic contractility.Recent researches showed that olprinone could inhibit the accumulation of inflammatory cells and inflammatory cytokine production,because it could increase cAMP.Olprinone can provide anti-inflammation effect and organ protection and can be used to prevent ischemia-reperfusion injury of organs under a variety of pathophysiological situations.In this article,we reviewed the chemical properties,pharmacological mechanism and clinical pharmacology of olprinone,and focused on its progress and mechanisms.