Wen-wu Liu, Jingda Li, Xuemei Zhang
Aug 26, 2020
Citations
2
Influential Citations
46
Citations
Journal
Journal of agricultural and food chemistry
Abstract
Caffeoylquinic acids (CQAs) are a broad class of secondary metabolites that have been found in edible and medicinal plants from various families. It has been 100 years since the discovery of chlorogenic acid in 1920. In recent years, a number of naturally derived CQAs have been isolated and structurally elucidated. Accumulated evidences demonstrate that CQAs have a wide range of biological activities, such as anti-oxidation, anti-bacterial, anti-parasitic, neuroprotective, anti-inflammatory, anti-cancer, anti-viral, and antidiabetic effect. Up to date, some meaningful progresses on the biosynthesis and total synthesis of CQAs have also been made. Therefore, it is necessary to comprehensively summarize the structure, biological activity, biosynthesis and chemical synthesis of CQAs. This review provides extensive coverage of naturally occurring CQAs discovered from 1990 until 2020. Modern isolation techniques, chemical data (including structure, biosynthesis, and total synthesis) and bioactivity are summarized. This would be helpful for further research of CQAs as potential pharmaceutical agents. Key words: Caffeoylquinic acids; Chlorogenic acid; Structure; Biosynthesis; Total synthesis; Bioactivity. .