Zhang Guobao
2012
Citations
0
Influential Citations
1
Citations
Journal
Chemical Industry and Engineering Progress
Abstract
1,2,3,4-tetrahydroquinoline derivatives are important intermediates of cardiovascular drugs and dye.The recent advances in the synthesis and application of 1,2,3,4-tetrahydroquinoline derivatives are reviewed in this paper.Different synthetic methods,including hydrogenation reaction,Diels-Alder reaction,multi-step reaction,multi-component reaction,and domino reaction,are compared,and the applications of 1,2,3,4-tetrahydroquinoline derivatives in medicinal chemistry and dye are also discussed.From the view of synthesis and practical applications,the research perspective of 1,2,3,4-tetrahydroquinoline derivatives is outlined in the end of this paper,which are the development of atom-economic methods and the synthesis and application of enantiomerically pure 1,2,3,4-tetrahydroquinoline derivatives.