A. Parmar, Harish Kumar, S. S. Marwaha
Jul 1, 2000
Citations
2
Influential Citations
122
Citations
Quality indicators
Journal
Biotechnology advances
Abstract
This article elaborates on the important recent developments in the enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA), which is the basic raw material for the industrial production of semisynthetic penicillins such as amoxycillin and ampicillin. Particular emphasis is placed on the improvements in purification, stability, and immobilization of the enzymes, (i.e. penicillin acylases) used for these transformations.