Wei Zhu, Jiang Wang, Shuni Wang
Nov 1, 2014
Citations
1
Influential Citations
320
Citations
Quality indicators
Journal
Journal of Fluorine Chemistry
Abstract
Abstract This review provides a brief assessment of the methodological field of trifluoromethylation and its possible impact on the development of new CF 3 -containing pharmaceuticals. Structural aspects of five new drug-candidates, [tafenoquine (aromatic CF 3 ), roniciclib (heteroaromatic CF 3 ), BAY-38-7271 (aliphatic CF 3 ), sonidegib (O CF 3 ) and navitoclax (S-CF 3 )] currently under the development in phase II and III clinical studies, and their biological properties, therapeutic area and synthesis are critically discussed.