S. Murahashi, Naruyoshi Komiya, Hiroyuki Terai
Nov 20, 2003
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Journal
Journal of the American Chemical Society
Abstract
RuCl3-catalyzed oxidative cyanation of tertiary amines with sodium cyanide under molecular oxygen (1 atm) at 60 degrees C gives the corresponding alpha-aminonitriles, which are versatile synthetic intermediates of various compounds such as amino acids and unsymmetrical 1,2-diamines, in excellent yields. This reaction is clean and should be an environmentally benign and useful process.