T. Davies, Wenchi Shang, K. Bush
Feb 4, 2008
Citations
10
Influential Citations
119
Citations
Quality indicators
Journal
Antimicrobial Agents and Chemotherapy
Abstract
ABSTRACT Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with doripenem.