D. C. Remy, W. A. Van Saun, E. Engelhardt
Feb 1, 1975
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0
Influential Citations
9
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Quality indicators
Journal
Journal of medicinal chemistry
Abstract
The synthesis of a series of 2-, 3-, and 4-substituted benzylamine derivatives is described. These compounds were studied for their effect on experimental cardiac arrhythmias. Many of the derivatives, but in particular 2-(p-methoxyphenylethynyl)benzylamine (3d), alpha,alpha-dimethyl-4y(phenylethynyl)benzylamine (7a), and alpha,alpha-dimethyl-4-phenethylbenzylamine (12g), showed good antiarrhythmic activity.