E. T. Michalson, J. Szmuszkovicz
1989
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0
Influential Citations
82
Citations
Quality indicators
Journal
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
Abstract
The 1,2-diamine (vicinal diamine) functionality is a remarkable template which displays a broad spectrum of biological activity. For the purpose of this review, molecules possessing two nitrogen atoms separated by two carbon atoms, at least one of which being sp3-hydridized, will be considered to be 1,2-diamines. Structural units such as piperazine and imidazolidine will be included as examples of 1,2-diamines. The 1,2-diamine conformation may be found in many important compounds including antiarrhythmics, antihypertensives, antipsychotics, analgesics, antianxiety agents, local anesthetics, anticonvulsants, gastrointestinal agents, anticancer drugs, and antiparasitic agents. The number of compounds falling into the 1,2-diamine category as defined above is considerable. Consequently, this review is intended to be illustrative rather than exhaustive.