G. Pettit, A. Numata, C. Iwamoto
Nov 7, 2002
Citations
1
Influential Citations
37
Citations
Journal
Journal of Natural Products
Abstract
The bark of the giant neem tree Melia dubia was found to contain 11 euphane-type triterpenes. Five new compounds, meliastatins 1−5 (1−5), proved to inhibit growth of the P388 lymphocytic leukemia cell line (ED50 1.7−5.6 μg/mL). Four of the others, the previously known methyl kulonate (8), kulinone (9), 16-hydroxybutyrospermol (10), and kulactone (11), were also found to inhibit (ED50 2.5−6.2 μg/mL) the P388 cancer cell line. In addition, two new euphane triterpenes were isolated and named dubione A (6) and dubione B (7). Structures for each of the 11 euphane triterpenes were established by spectral techniques that included HRMS and 2D NMR.