D. A. Walsh, H. W. Moran, D. A. Shamblee
Nov 1, 1984
Citations
0
Influential Citations
71
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 157 (4'-chloro), 158 (4'-bromo), and 182 (5-chloro, 4'-bromo) were more potent than indomethacin in these assays.