Domenico Regoli, Guy Drapeau, S. Dion
Aug 1, 1988
Citations
4
Influential Citations
350
Citations
Quality indicators
Journal
Trends in pharmacological sciences
Abstract
Abstract The neurokinin system is replete with a multiplicity of endogenous ligands (substance P, neurokinin A, neurokinin B) and their receptors (NK 1 , NK 2 and NK 3 ). Neurokinin receptors have previously been studied almost exclusively with natural — but non-selective — agonists. However, new selective agonists have now been developed . Domenico Regoli and colleagues describe how such compounds have been successfully used in vitro to characterize the responses of peripheral organs to neurokinins, and in vivo to elucidate possible physiological roles of the neurokinin system .