A. Okamoto, K. Kumeda, N. Yonezawa
Jan 16, 2010
Citations
0
Influential Citations
7
Citations
Journal
Chemistry Letters
Abstract
The CF 3 group in 4-trifluoromethylbenzoyl chloride is efficiently diarylated and converted into a diarylhydroxymethyl group by treatment with AlCl 3 in the presence of an excess amount of halobenzene (C 6 H 5 X; X = F, Cl, and Br). The diarylation is followed by arylation of the chlorocarbonyl group to afford triarylated products, diarylhydroxymethylated benzophenones. The employment of TfOH in place of AlCl 3 promotes the exclusive arylation of the chlorocarbonyl group leaving the CF 3 group unchanged to afford selectively 4-trifluoromethylbenzophenones, which then undergo diarylhydroxymethylation with the aid of AlCl 3 .