Tsuzuki Noriko, Wong Ooi, Higuchi Takeru
Sep 1, 1988
Citations
0
Influential Citations
25
Citations
Quality indicators
Journal
International Journal of Pharmaceutics
Abstract
Abstract The penetration enhancement of indomethacin by a series of primary alcohols with alkyl chains (C4–C16) was evaluated by the steady-state flux of indomethacin through shed skin of black rat snake. A parabolic relationship between the enhancement and the carbon atom number of the alcohols was established with tridecanol showing the maximum effect.