Sushovan Paladhi, Ajay Chauhan, Kalyan Dhara
Oct 24, 2012
Citations
0
Influential Citations
34
Citations
Journal
Green Chemistry
Abstract
Thiazolidinediones have been used as aldol donors with aromatic aldehydes “on water” and in DMSO without using any catalyst to give the corresponding β-hydroxy carbonyl compounds in high yield and purity. The p-cyano and p-nitro substituted aldol products undergo syn/anti isomerization via an enolization mechanism providing an “on water” diastereoselectivity switch. Water molecules play a significant role in stabilizing the syn aldol products of pyridine and thiazole containing aldehydes.