Hai-Min Shen, Hongbing Ji
Jul 11, 2012
Citations
0
Influential Citations
25
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Two proline derivatives, ( S )-2-aminomethylpyrrolidine and ( R )-2-aminomethylpyrrolidine modified β-CD ( CD - 1 , CD - 2 ) were synthesized in the yields of 31% and 14%. Their self-inclusion conformations were characterized by 1 H ROESY NMR studies and quantum calculation. When CD - 1 was applied to asymmetric aldol reactions, up to 94% ee was obtained. Substrate selectivity was also observed in these asymmetric aldol reactions.