C. Kashima, S. Tobe, N. Sugiyama
1973
Citations
0
Influential Citations
25
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
3,5-Dimethylisoxazole (1) was alkylated with sodium amide in liquid ammonia to give 3-methyl-5-alkylisoxazoles. By di- and tri-alkylation reactions using excess sodium amide, isoxazoles having secondary and tertiary alkyl groups at 5-position could be obtained. The hydrogenolysis and hydrolysis of these isoxazoles were also studied.